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DeCS
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Descriptor English:
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Kelch-Like ECH-Associated Protein 1
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Descriptor Spanish:
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proteína 1 asociada a ECH tipo Kelch
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Descriptor Portuguese:
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Proteína 1 Associada a ECH Semelhante a Kelch
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Synonyms English:
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KEAP 1 Protein
KEAP-1 Protein
KEAP1 Protein
Kelch Like ECH Associated Protein 1
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Tree Number:
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D12.644.360.024.306
D12.776.157.057.067
D12.776.476.024.387
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Definition English:
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An adaptor protein characterized by an N-terminal BTB-POZ DOMAIN and six KELCH REPEATS that functions as a substrate for the E3 UBIQUITIN LIGASE complex. It negatively-regulates NF-E2-RELATED FACTOR 2 by targeting it for ubiquitination and degradation by the PROTEASOME. It also represses genes regulated by ANTIOXIDANT RESPONSE ELEMENTS. |
History Note English:
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2017
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Allowable Qualifiers English:
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Record Number:
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56536
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Unique Identifier:
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D000072019
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Occurrence in VHL:
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Similar:
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DeCS
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